Holography and Brain Function
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چکیده
&rep is the probability a subunit is in the open conformation, 7(V) and flv) describe the voltage dependent relaxation ,;me constant and steady state probability of the subunit being ,pen. T(V) andffV) must be determined emperically from volt,ge clamp experiments. For the sodium channel, the subunit ,pen probabilities are denoted by m and h (replacing p in the ,quation). The assumption that the activation subunits are identical and that all subunits open and close independently implies, then, that the sodium conductance is proportional to m3h. For the potassium channel (where inactivation is neglected), the open probability is denoted by n (replacing p in the equation). the assumption of four identical and independent subunits implies that the potassium conductance is proportional to n4. Modern treatments of channel behavior still often view subunits as being governed by a single relaxation time constant, but recent evidence indicates that the various subunits are not identical and independent so that the descriptive equations are more complex. The overall goal of all theories is still, however, to derive the coupling between subunits, and their relaxation time constants T(V) and steady state open probabilities f fV) as a function of voltage. As the structure of channel proteins becomes available, the goal will be to relate the Hodgkin and Huxley subunits to identified polypeptide chains, and to explain the rate constants in the Hodgkin and Huxley treatment
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تاریخ انتشار 2010